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KMID : 0380620210530030304
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Korean Journal of Food Science and Technology
2021 Volume.53 No. 3 p.304 ~ p.312
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Immuno-stimulating and anti-metastatic activities of the polysaccharides isolated from Angelica gigas
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Son Seung-U
Shin Kwang-Soon
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Abstract
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The present study aimed to develop new physiologically active ingredients from Angelica gigas. The polysaccharides purified from A. gigas, AGE-2c-I, showed potent anti-complementary activity in a dose-dependent manner.
C3 activation products were identified through crossed immuno-electrophoresis using anti-human C3 antibodies and the anticomplementary activity of AGE-2c-I under Ca++-free conditions suggests that AGE-2c-I may induce complementary activation via both alternative and classical pathways. In addition, AGE-2c-I augmented the production of various cytokines, such as interleukin (IL)-6, IL-10, IL-12, and tumor necrosis factor-α, by peritoneal macrophages. Furthermore, intravenous (i.v.) administration of AGE-2c-I dose-dependently enhanced natural killer cell cytotoxicity against YAC-1 lymphoma. In experimental lung metastasis, prophylactic i.v. administration of AGE-2c-I inhibited lung metastasis by 58% at 100 μg/mouse. From the above results, we suggest that AGE-2c-I purified from A. gigas has potent immune systemstimulating activities, and is a potentially promising food ingredient beneficial to human health.
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KEYWORD
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Angelica gigas, complement system, macrophage, NK cell, metastasis
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